用于通过调节翻译后修改来治疗肝纤维化的天然药物
Qun Niu1,2, Yu Mou1, Kaixin Wang1,2
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in pharmacology
|November 26, 2025
概括
翻译后修改 (PTMs) 通过改变蛋白质功能,显著影响肝纤维化. 自然产品通过准这些PTM调节的纤维化通路,提供了潜在的治疗策略.
科学领域:
- 生物化学和分子生物学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝纤维化涉及肝星细胞激活,免疫细胞参与和细胞因子信号传递,导致过度的细胞外基质沉积.
- 翻译后修改 (PTMs) 关键调节蛋白质功能,包括稳定性,局部化,相互作用和活性,影响纤维基因通路.
- 目前的抗纤维菌疗法在临床疗效和耐受性方面是有限的.
研究的目的:
- 审查PTMs在肝纤维化开始和进展中的核心作用.
- 为了合成特定的PTM如何调节纤维细胞通路.
- 评估天然产品作为潜在的治疗药物,针对PTM调节纤维生成.
主要方法:
- 文献综述侧重于PTM和肝纤维化之间的相互作用.
- 在纤维生成中分析PTM (酸化,乙化,无化,糖化,化,甲基化).
- 对针对PTM调节纤维结节的天然产品的评估.
主要成果:
- PTMs是肝脏中纤维化过程的关键调节者,在各种疾病阶段.
- 特定的PTM极大地推动了肝纤维化的开始和进展.
- 自然产品通过准PTM调节的途径,显示出作为抗纤维素剂的潜力.
结论:
- 了解肝纤维化中的PTM对于开发有效的抗纤维菌治疗至关重要.
- 天然产品通过向PTMs来为抗纤维菌药物发现提供了一个有希望的途径.
- 应加快针对PTM信息的抗纤维菌治疗开发策略.
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