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案例报告:皮肤转移性乳腺腺癌产生乳腺素的前列腺腺癌
Ahmet M Yildirim1, Douglas Semler2, Jeffrey Harvell3
1Department of Internal Medicine, Inova Fairfax Hospital, Falls Church, VA, United States.
Frontiers in oncology
|November 26, 2025
概括
皮肤前列腺癌转移是罕见的,经常模仿其他皮肤疾病. 这一案例凸显了皮肤活检和老年男性PSA查对于早期诊断晚期前列腺癌的重要性.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 来自前列腺腺癌的皮肤转移是罕见的 (<1%的皮肤转移).
- 它通常在疾病的晚期呈现,模仿良性或原发性皮肤瘤.
- 早期检测对于管理先进的内部恶性瘤至关重要.
研究的目的:
- 报告一个罕见的前列腺腺癌单一皮肤转移病例.
- 强调皮肤活检对非典型病变的诊断意义.
- 提高人们对老年患者皮肤转移的前列腺癌的认识.
主要方法:
- 皮肤的组织病理学检查.
- 免疫组织化学检查以确定瘤的起源 (PSAP+,NKX3.1+).
- 血清前列腺特异性抗原 (PSA) 测试和PET/CT成像用于分期.
主要成果:
- 组织病理学揭示了一种皮肤恶性腺体瘤,通过免疫组织化学确认为前列腺腺癌.
- 血清PSA升高 (30.49 ng/mL) 和广泛的转移性疾病被检测到,尽管正常的数字直肠检查.
- 患者接受了安德روج因剥夺疗法 (relugolix).
结论:
- 皮肤活检对于诊断非典型皮肤病变至关重要,特别是在老年患者中.
- 前列腺癌可以呈现为单独的皮肤转移,即使症状很小.
- PSA查可能有利于选择老年患者,有助于早期诊断晚期前列腺癌.
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