式肺栓塞二次性氧化使用:一个案例报告和文献综述
Carlos Valladares1, Carlos Nuñez2, Erick Villacis3
1Pulmonary and Critical Care, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, USA.
Cureus
|November 26, 2025
概括
娱乐性氧化 (N2O) 的使用可以通过降低维生素B12而导致严重的血栓,如式肺栓塞. 这一案例凸显了在无法解释的血栓形成中,特别是年轻人中,考虑N2O滥用的重要性.
科学领域:
- 医学案例研究 医学案例研究
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
背景情况:
- 马肺栓塞 (SPE) 是一种罕见的,危及生命的静脉血栓塞 (VTE) 形式.
- 娱乐用氧化 (N2O) 的使用正在增加,并且与维生素B12缺乏,同类半氨酸水平升高和前血栓状况有关.
研究的目的:
- 报告SPE和深静脉血栓塞 (DVT) 的病例,该病例发生在一个有N2O滥用史的年轻成年人身上.
- 为了强调N2O使用,维生素B12缺乏和血栓事件之间的联系.
主要方法:
- 一个31岁的男性患有呼吸障碍和小腿疼痛的案例介绍.
- 诊断工作包括肺栓塞和DVT的成像.
- 实验室分析维生素B12和同类半氨酸水平.
主要成果:
- 这名患者被诊断为坐肺栓塞和右腿深静脉血栓症.
- 实验室调查结果显示,维生素B12的含量较低,homocysteine的含量较高.
- 患者成功地接受了抗凝药治疗.
结论:
- 滥用N2O可以导致严重的血栓形成事件,如SPE和DVT.
- 临床医生应考虑N2O暴露在无法解释的血栓形成的差异诊断中,特别是在年轻人中.
- 早期识别和管理N2O诱导的维生素B12缺乏症对于预防血栓栓塞并发症至关重要.
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