尿液碳水化合物抗原19-9在患有单侧泌尿交道阻塞的儿童:膀尿液是否反映了盆的变化?
Ashwin Rajkumar1, Sangeetha Geminiganesan1, Arunaa Sathyamurthy1
1Department of Paediatric Urology and Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Journal of Indian Association of Pediatric Surgeons
|November 26, 2025
概括
尿中碳水化合物抗原19-9 (CA 19-9) 在患有尿管盆结阻塞 (UPJO) 的儿童中升高. 膀尿中的CA 19-9水平准确地反映了骨中的度,支持非侵入性UPJO诊断.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 生物标志物发现发现
- 诊断成像 诊断成像 诊断成像
背景情况:
- 尿道盆腔结阻塞 (UPJO) 是儿童常见的一种先天性异常.
- 对于UPJO诊断的非侵入性生物标志物非常受欢迎.
- 尿中的碳水化合物抗原19-9 (CA 19-9) 显示出作为诊断标记物的潜力.
研究的目的:
- 评估尿路CA 19-9在儿科UPJO的诊断效用.
- 为了确定膀尿中的CA 19-9水平是否与脏骨盆水平相关.
- 评估非侵入性UPJO诊断的可行性,使用膀尿液CA 19-9.
主要方法:
- 对72名儿童进行前性病例控制研究 (34名UPJO,38名对照).
- 从膀和骨盆收集的尿样 (在UPJO组的手术期间).
- 使用酶相关免疫吸收试验 (ELISA) 测量CA 19-9水平.
主要成果:
- 与对照组相比,UPJO组 (盆腔和膀) 的CA 19-9中位数显著更高 (P=0.001).
- 在UPJO患者中,膀和盆腔CA 19-9水平之间没有显著差异 (P=0.134).
- 盆腔和膀CA 19-9水平之间的中等正相关性 (r=0.6055).
结论:
- 在患有UPJO的儿童中,尿液CA 19-9显著升高.
- 膀尿中的CA 19-9水平可靠地反映了脏盆腔度.
- 膀尿液CA 19-9测试为UPJO诊断和监测提供了一种非侵入性的方法.
相关概念视频
Urine Studies I: Urinalysis
1.1K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.1K
Imaging Studies V: Intravenous Urography and Retrograde Pyelography
995
IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
995
Imaging Studies I: Kidney, Ureter, and Bladder Studies
246
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
246
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
354
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
354
Imaging Studies II: Ultrasonography
330
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
330
Ureters
1.4K
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
1.4K


