如何使用超出官方指示的新型抗微生物药物:专家共识
Pilar Retamar-Gentil1,2, María Alegre-Albendea1, Lucía Valiente De Santis3
1Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Instituto de Biomedicina de Sevilla (IBIS)/CSIC, Departamentos de Medicina, Universidad de Sevilla, Sevilla, Spain.
JAC-antimicrobial resistance
|November 26, 2025
概括
这项研究建立了专家的共识,在西班牙使用新的抗微生物药物非标签. 指导方针有利于针对特定感染的有针对性的使用,支持抗微生物药物管理,并尽量减少耐药性.
科学领域:
- 传染性疾病 传染性疾病
- 临床药房 临床药房
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 新的抗微生物药物提供了新的治疗选择,但非标签使用需要仔细考虑.
- 抗菌药物管理计划 (ASP) 需要基于证据的指导来优化新药的使用.
- 区域共识对于将指导方针适应当地需求和抵抗模式至关重要.
研究的目的:
- 为了在最近批准的抗微生物药品的非标签说明方面达成区域专家共识.
- 支持在西班牙安达卢西亚开发和实施有效的抗微生物管理计划 (ASP).
- 为合理使用新型抗生素提供基于证据的建议.
主要方法:
- 一个经过修改的Delphi方法,涉及32名传染病和重症监护专家.
- 三轮调查评估了八种新的抗菌剂的非标签用途.
- 评估标准包括有效性,安全性,生态影响,成本和PK/PD优势.
主要成果:
- 对于大多数药物的特定非标签向用途达成共识,但不包括ceftobiprole.
- 经验性使用通常不鼓励,除非存在明显的优势.
- 达尔巴万辛,塞法托林和塞法齐迪姆-阿维巴克坦已获得批准,用于针对性地治疗严重感染,如内心炎和细菌血症.
结论:
- 共识支持在定义的临床场景中明智地在标签之外使用新的抗微生物药物.
- 指导优先考虑针对性的实证治疗,与全球ASP原则保持一致.
- 该区域参考优化了新抗生素的使用,最大限度地减少了生态影响和耐药性发展.
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