Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The clinical and molecular landscape of thalamic glioma.

Neuro-oncology·2026
Same author

Human Hematopoietic Stem Cells Enhance Maturational Differentiation of hiPSC-Derived Cardiomyocytes on Xeno-Free MatriClone-Plastic via EGFR/MAPK/ERK Signaling Pathway.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Global trends and hotspots of artificial intelligence in pain management: A bibliometric analysis.

Digital health·2026
Same author

Friend or Foe? The Dual Role of Ferroptosis in Tumor Immunity and Immunotherapy.

WIREs mechanisms of disease·2026
Same author

Selective blockade of γc pathway ameliorates alopecia areata in a humanized murine model.

The Journal of investigative dermatology·2026
Same author

Novel multiple-image encryption with ultrafast light springs.

Scientific reports·2026
Same journal

Association Between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality and Cardiovascular Events in Patients with Diabetic Foot Ulcers: A Retrospective Cohort Study.

Journal of inflammation research·2026
Same journal

R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis.

Journal of inflammation research·2026
Same journal

Peripheral Blood Mononuclear Cells in Sepsis: Immune Trajectories, Monocyte Dysfunction, and Translational Biomarkers.

Journal of inflammation research·2026
Same journal

PD-1/TIGIT CD4⁺ T-Cell Signature for Risk Stratification of Post-Weaning Mortality in Venoarterial Extracorporeal Membrane Oxygenation Patients.

Journal of inflammation research·2026
Same journal

Development and Validation of an Early Severity Prediction Model for Hypertriglyceridemia-Associated Acute Pancreatitis: A Multicenter Cohort Study.

Journal of inflammation research·2026
Same journal

Comparative Evaluation of Prolonged Dual Antiplatelet Therapy versus Conventional Regimens on Prognosis in Patients with High Residual Inflammatory Risk: Results from a Prospective Observational Study.

Journal of inflammation research·2026
查看所有相关文章

相关实验视频

Updated: Jan 10, 2026

Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
09:12

Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis

Published on: October 17, 2018

58.7K

单细胞转录组学揭示了CCL3+ 经典单细胞子集与自身免疫病原发生相关.

Heng Xu1, Kai Yuan1, Guangyao Chen2

  • 1School of Life Sciences, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Journal of inflammation research
|November 26, 2025
PubMed
概括
此摘要是机器生成的。

研究人员发现了一种新的免疫细胞子集,CCL3+经典单细胞 (cMo),在多种自身免疫性疾病中被放大. 这些炎症性cMo细胞可能是狼和类风湿性关节炎等疾病的关键治疗点.

关键词:
CCL3+ 经典单细胞自身免疫性疾病 自身免疫性疾病单核细胞 (单核细胞) 是一种单核细胞.主要的斯约格伦综合征.一个单细胞RNA测序.

更多相关视频

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.8K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.1K

相关实验视频

Last Updated: Jan 10, 2026

Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
09:12

Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis

Published on: October 17, 2018

58.7K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.8K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.1K

科学领域:

  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.
  • 自身免疫性疾病的发病因子

背景情况:

  • 单核巨分化状态在自身免疫性疾病的发展中至关重要.
  • 了解免疫细胞异质性是推动自身免疫性疾病治疗的关键.

研究的目的:

  • 在六种自身免疫性疾病中对单核巨细胞的共同和疾病特异性改变的特征.
  • 识别涉及自身免疫病原发生的新型免疫子集.
  • 完善自身免疫性疾病的临床治疗策略.

主要方法:

  • 六种自身免疫性疾病的综合单细胞RNA测序 (scRNA-seq) 数据.
  • 分析了来自患者和健康对照的350,043个外周血液免疫细胞.
  • 使用流细胞计,免疫组织化学染色和免疫光学验证的结果.

主要成果:

  • 确定了15个单核细胞亚群,包括一个新的CCL3+经典单细胞 (cMo) 亚群.
  • 在贝塞特病,青少年皮肤肌炎,初级Sjogren综合征,复发性复发性多发性硬化症和全身性红斑狼中,CCL3+cMo细胞被共同放大.
  • 这些细胞表现出类似M1的炎症特征,高化学反应,并与CD8+ T细胞交叉交流.

结论:

  • 概述了自身免疫性疾病中的单核细胞场景.
  • 揭示了CCL3+ cMo作为一种与多种自身免疫性疾病相关的常见放大免疫子集.
  • 指定CCL3+cMo作为自身免疫性疾病的潜在治疗点.