在体内量化口腔下粘膜纤维化中的粘弹性性质变化,使用光学连贯弹性学
Xiao Han1,2, Yubao Zhang2,3, Jiahui Luo2
1School of Instrument Science and Opto-Electronics Engineering, Beihang University, Beijing, China.
Biomedical optics express
|November 26, 2025
概括
使用光学连贯弹性图 (OCE) 进行口腔下粘膜纤维化 (OSF) 的定量分析显示了显著的生物机械变化. 这项技术通过测量组织粘性弹性来准确跟踪疾病的进展和潜在的恶性转变.
科学领域:
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
- 病理学 病理学 病理学
背景情况:
- 口腔膜纤维化 (OSF) 是一种癌前疾病,其特征是渐进性纤维化和口腔开口缩小.
- 监测OSF进展和预测恶性转变对于患者管理至关重要.
- 在OSF中缺乏组织变化的定量生物力学评估.
研究的目的:
- 开发和验证基于压电的光学连贯弹性图 (OCE) 系统,用于实时,in vivo OSF进展的定量评估.
- 为了将定量粘弹性参数与不同阶段的OSF相关联.
- 探索OCE在预测恶性转变风险方面的潜力.
主要方法:
- 一个基于压电的光学连贯弹性图 (OCE) 系统被开发用于体内测量.
- 十六只老鼠被分为四组,代表渐进性纤维化阶段.
- 阶段敏感的OCE测量捕获了弹性波传播,并分析了相速分散和波衰减的数据.
主要成果:
- 在所有纤维化阶段,OCE成功捕获了独特的弹性波纹.
- 随着疾病的进展,Young模量 (近四倍) 和粘度系数 (超过两倍) 显著增加.
- 损失因子 (G"/G oun) 显示出非单调的趋势,中度纤维化下降,严重纤维化略有增加.
结论:
- 来自OCE的定量粘弹性参数与OSF进展相关.
- OCE提供了一种非侵入性方法,用于实时监控OSF.
- 来自OCE的粘弹性参数可能有助于精确的OSF分期和早期恶性瘤风险评估.
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