相关实验视频

Updated: May 11, 2026

Photoacoustic Cystography

Photoacoustic Cystography

Published on: June 11, 2013

使用外源分子对比剂进行光声学成像的临床翻译 [受邀]

Jingyi Miao¹, Mingze Luo¹, Alankar Kotwal^1,2

¹Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston 77005, USA.

Biomedical optics express

|November 26, 2025

概括

与对比度增强的光声学成像 (PAI) 在临床深度提供高分辨率的分子成像. 本次审查强调了其当前在人类健康中的应用和未来潜力,重点关注监管方面和各种器官系统用途.

科学领域:

医疗成像医学成像
生物医学工程生物医学工程
光学物理学光学物理学

背景情况:

光声成像 (PAI) 集成光学对比度与声学检测,用于高分辨率的分子成像.
临床翻译PAI正在推进,重点是人类应用的对比增强技术.
监管障碍和对标准化验证协议的需求影响了新型对比剂的批准.

研究的目的:

审查对比增强PAI在人类应用中的当前状态和未来潜力.
讨论PAI设备和对比剂的监管考虑因素.
探索各种临床应用和PAI的新兴进展.

主要方法:

对人类研究中的对比增强PAI现有文献的审查.
讨论PAI对比剂的监管途径和挑战.
在各种器官系统 (淋巴,前列腺,血管,胃肠道,肝脏,神经瘤学) 中对PAI应用的分类.

主要成果:

重用FDA批准的药物 (例如,绿色氨酸,甲蓝色) 加快了临床采用.
PAI在淋巴成像,前列腺癌划分,血管评估和胃肠道/肝脏病变检测方面具有实用性.
新兴应用包括神经瘤学中的手术内指导和改进的瘤边缘成像.

结论:

与光成像相比,对比增强的PAI提供了显著的优势,包括更深的透和可量化的对比.
跨皮PAI和分子探针设计的进步正在扩大其能力.
这种PAI准备在更广泛的临床采用中,使实时,功能和分子成像成为可能.

更多相关视频

A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging

A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging

Published on: June 21, 2017

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

相关概念视频

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...