设计和实施多式多功能OCT综合扫描协议
Zhengshuyi Feng1, Tianyu Zhang1, Mingkai Wang2
1Healthcare Engineering, School of Physics and Engineering Technology, University of York, UK.
Biomedical optics express
|November 26, 2025
概括
一个新的扫描协议整合了光学连贯性断层扫描 (OCT) 结构成像,光学连贯性弹性扫描 (OCE) 和基于OCT的血管造影 (OCTA) 进行全面的皮肤评估. 这种非侵入性技术有助于区分良性与恶性皮肤病变.
科学领域:
- 生物医学光学 生物医学光学
- 皮肤病学 皮肤病学
- 医疗成像医学成像
背景情况:
- 早期诊断皮肤病变对于有效治疗至关重要.
- 像光学连贯断层扫描 (OCT) 这样的非侵入性技术对于皮肤评估有价值.
- 整合OCT结构成像,光学连贯弹性成像 (OCE) 和基于OCT的血管造影 (OCTA) 由于图像注册的困难而存在挑战.
研究的目的:
- 开发和验证一种用于同时获取OCT,OCE和OCTA的新型扫描协议.
- 为了使皮肤组织特性和血管网络的全面,非侵入性表征.
- 为了更准确地区分良性和恶性皮肤病变.
主要方法:
- 使用扫描源OCT (SS-OCT) 系统将结构成像,OCE和OCTA集成到一个扫描过程中.
- 招募了11名健康参与者,从手掌,前臂和面部皮肤获取数据.
- 从OCE计算的生物力学参数 (Young的模量) 和来自OCTA的血管网络指标 (VAD,VSD,VDI,WTI).
主要成果:
- 从健康的人类皮肤中成功获取集成的OCT,OCE和OCTA数据.
- 在健康的面部皮肤和一个收集的面部病变数据集之间展示了不同的生物机械和血管参数.
- 新协议允许从单次扫描中计算关键皮肤参数.
结论:
- 综合扫描协议为皮肤评估提供了一个全面的,非侵入性的方法.
- 这种方法为皮肤科医生提供了宝贵的数据,有助于皮肤疾病的研究和诊断.
- 潜在的好处包括改善皮肤病变的分化和提高对皮肤病理生理学的理解.
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