脑下垂体激素缺陷:患病率,预测因素和功能恢复
Antonio Prinzi1,2, Ginevra Fava1, Ignazio Bacchi3
1Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Frontiers in endocrinology
|November 26, 2025
概括
垂体激素缺乏症在益生菌瘤患者中很常见,特别是在较大的瘤患者中. 瘤大小预测缺陷和恢复,强调需要长期监测.
科学领域:
- 内分泌学 在内分泌学.
- 神经瘤学神经瘤学
- 在瘤学瘤学.
背景情况:
- 甲状腺瘤,垂体瘤分泌甲状腺素,可以导致荷尔蒙缺乏.
- 了解这些缺陷的患病率和预测因素对于患者管理至关重要.
研究的目的:
- 为了确定脑下垂体激素缺陷的频率在益生菌瘤患者.
- 在诊断时确定预测非淋巴体下垂体病的因素.
- 评估随着时间的推移垂体功能恢复的潜力.
主要方法:
- 对145名在2000年至2024年期间被诊断为前乳腺瘤的患者进行了回顾性多中心研究.
- 在诊断和随访期间对所有前垂体轴进行全面评估.
- 对激素缺乏和恢复的临床和放射学预测因素的分析.
主要成果:
- 37.2%的患者在诊断时患有垂体激素缺乏症;最常见的是阴性腺体缺陷症.
- 非淋巴体下垂体发生在14.5%的人群中,瘤大小是唯一的独立预测因素 (OR: 1.1).
- 17毫米的瘤大小最好地预测了非淋巴体缺陷;在随访期间,66.7%的功能恢复了,特别是较小的瘤.
结论:
- 非淋巴体下垂体症在益生菌瘤中普遍存在,特别是大型的.
- 瘤大小 (≥17毫米) 是激素缺陷存在和恢复的关键预测因素.
- 长期随访对于评估垂体功能恢复至关重要,特别是对于淋巴腺和上腺轴.
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