刺激性肠综合征和甲状腺功能低下症之间的关联:来自大规模基于人口的研究的见解
Jing Wu1,2,3,4,5,6, Ziwei Liu1,2,3,4,5,6, Luna Liu1,2,3,4,5,6
1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Endocrine, metabolic & immune disorders drug targets
|November 26, 2025
概括
刺激性肠综合征 (IBS) 与患甲状腺功能低下症的风险更高有关. 这一发现表明,在IBS患者中查甲状腺功能障碍可能会改善健康结果.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 刺激性肠综合征 (IBS) 和甲状腺功能低下症是影响患者健康的普遍疾病.
- 了解IBS和甲状腺功能低下症之间的关系对于有效的患者管理至关重要.
研究的目的:
- 调查刺激性肠综合征 (IBS) 和随后患甲状腺功能低下症的风险之间的关联.
- 为了确定IBS是否是甲状腺功能低下症的独立风险因素.
主要方法:
- 使用英国生物库 (UKB) 数据和全国住院患者样本 (NIS) 的横截面分析进行的回顾性队列研究.
- 使用倾向分数匹配 (PSM) 来控制混变量.
- 考克斯比例危险模型 (UKB) 和后勤回归 (NIS) 用于评估IBS-甲状腺功能减退的联系,并根据年龄和性别对子组进行分析.
主要成果:
- 在UKB队列中,IBS患者的甲状腺功能低下患病率为4.1%,非IBS对照组为2.9%.
- 在NIS队列中,IBS患者的甲状腺功能低下患病率为20.6%,而非IBS参与者则为10.3%.
- 在PSM之后,IBS与UKB中甲状腺功能低下的1.21危险比率 (P < 0.001) 和NIS中1.25概率比率 (P < 0.001) 相联系,女性和年龄 ≤65.5岁的人群中观察到风险增加.
结论:
- 刺激性肠综合征 (IBS) 与甲状腺功能低下症的风险显著增加有关.
- 这些发现强调了在被诊断为IBS的个人中考虑甲状腺查的重要性.
- 早期查可能会导致IBS患者和同时出现的甲状腺功能障碍患者的改善管理和结果.
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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01:17Chronic Bowel Disorders: Introduction
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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01:30Irritable Bowel Syndrome III: Medical and Nursing Management
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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01:30Inflammatory Bowel Disease II: Crohn's Disease
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
932