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Updated: Jan 10, 2026

Targeted DNA Methylation Analysis by Next-generation Sequencing

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

老龄化和发生心血管疾病的DNA甲基化算法:一项前性队列研究

Xian Cui¹, Chunbei Yi¹, Hui Zhang^2,3

¹Diagnostic Imaging Center, Shanghai Children's Medical Center School of Medicine, Shanghai Jiao Tong University Shanghai China.

Journal of the American Heart Association

|November 26, 2025

概括

DNA甲基化 (DNAm) 算法在预测老年人心血管疾病 (CVD) 风险方面表现有前途. 张_DNAmAge,甲基化衰老速度和DNAmGrimAgeAcc独立预测发生的心血管疾病,可能改善早期检测.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
老年学是一门学科.
心血管医学心血管医学

背景情况:

基于DNA甲基化 (DNAm) 的衰老算法是预测与年龄有关的疾病的新兴工具.
这些算法对预测发生心血管疾病 (CVD) 的比较实用性需要进一步研究.

研究的目的:

系统地比较13个DNA算法,以确定它们与老年人心血管疾病风险的关联.
评估不同DNAm老化时钟对事件CVD及其亚型的预测性能.

主要方法:

研究人员对来自美国健康与退休研究 (HRS) 的2112名参与者进行了前性队列研究.
使用Infinium MethylationEPIC BeadChip套件进行了DNAm分析.
考克斯的比例危险模型被用来评估13个DNA算法和CVD事件之间的关联.

主要成果:

在37个月的中位数随访期间,观察到288例心血管疾病病例.
张_DNAmAge,甲基化衰老速度 (mPoA) 和DNAmGrimAgeAcc与任何心脏病风险都有积极的关联.
DNAmGrimAge预测了充血性心力衰竭风险,而mPoA和HorvathAcc预测了中风风险.

结论:

张_DNAmAge,mPoA和DNAmGrimAgeAcc作为发生心血管疾病的独立预测因素.
这些表观遗传生物标志物可能会增强早期心血管疾病检测和老龄化人口的风险分层.

关键词:

通过DNA甲基化.年龄加速的加速度.心血管疾病心血管疾病表观遗传时钟的时间表.事件事件事件事件事件事件事件事件.

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Epigenetic Regulation

Epigenetic Regulation

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X-chromosome...

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.