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坎迪达阿尔比坎斯 (Candida albicans) 增强蛋白酶活性,并激活人类角质细胞中MyD88-依赖IL-1β的IL-1β产生

Jingyi Wang¹, Neil A R Gow², Matthew G Brewer¹

¹Department of Dermatology, University of Rochester, Rochester, New York, USA.

|November 26, 2025

概括

这项研究揭示了Candida albicans (一种常见的真菌) 如何在阿托皮炎 (AD) 中损害皮肤屏障功能. 它触发炎症和蛋白酶活性,通过影响角质细胞,恶化AD症状.

科学领域:

皮肤病学皮肤病学
菌类学菌类学是指菌类学.
免疫学免疫学免疫学

背景情况:

亚托匹性皮肤炎 (AD) 是一种慢性皮肤疾病,炎症和蛋白酶活性增加.
坎迪达阿尔比坎斯 (Candida albicans) 的殖民与阿尔茨海默病的严重程度有关,但其作用尚不清楚.

研究的目的:

研究C. albicans如何影响AD中的角质细胞 (KC) 功能.
确定对KC蛋白质溶解活性,炎症和屏障完整性的影响.
确定参与C. albicans诱导的AD病变发生的信号通路.

主要方法:

人类KCs与C. albicans的共同培养.
评估了KC蛋白酶活性和IL-1β分泌.
使用CRISPR/Cas9来创建缺乏MyD88或MMP-9的细胞系,以研究信号通路.

主要成果:

C. albicans通过MyD88信号传递诱导了KC蛋白质分解活性和IL-1β分泌.
这导致MMP-9表达/激活增加,皮肤屏障功能受损.
删除MyD88或MMP-9恢复了屏障功能,表明MMP-9是一个下游效应器.

结论:

在AD中建立了皮肤真菌和表皮屏障功能障碍之间的机械联系.
证明了一条C. albicans殖民引发皮肤细胞内天生的免疫反应的途径.
提供了关于C. albicans对AD病变发生的贡献的见解.

关键词:

这是一种Candida Candida.IL-1β是一种IL-1β.在MMP-9中,MMP-9是指MMP-9,MMP-9是指MMP-9.我的D8888是什么意思亚托邦性皮肤炎的发生.质细胞 (keratinocyte) 是一种细胞.这就是我的mycobiome.蛋白质酶蛋白质酶是一种蛋白质.

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