肝病和牙周病原体:肝脏和口腔微生物群之间的双向关系
Mario Dioguardi1, Eleonora Lo Muzio2, Ciro Guerra1
1Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.
Dentistry journal
|November 26, 2025
概括
牙周病,特别是由 Porphyromonas gingivalis 引起的牙周病,与通过炎症和微生物因素的肝损伤有关. 虽然因果关系尚未被证明,但治疗牙疾病可能有利于非酒精性脂肪性肝病 (NAFLD).
科学领域:
- 研究口腔健康和肝脏疾病的交叉点.
- 专注于牙周病原体的作用及其系统影响.
背景情况:
- 牙周失生症通过炎症和微生物转移促进肝损伤.
- Porphyromonas gingivalis (P. gingivalis) 的毒性因子可以激活肝脏中的炎症通路 (TLR,NF-κB).
研究的目的:
- 系统地审查临床证据,将牙周病原体与肝脏结果联系起来.
- 要突出微生物交叉在肝脏病理生理学中的作用.
主要方法:
- 对观察性研究和试验进行符合PRISMA的系统审查.
- 在PubMed,Scopus,Cochrane图书馆和灰色文学中进行了搜索.
- 评估了P. gingivalis和其他病原体与NAFLD/MASLD,纤维化,AAH和HCC的关联.
主要成果:
- 包括20项研究 (约34,000名参与者);在人口层面上,证据是矛盾的.
- 临床队列将牙周暴露,特别是P. gingivalis,与晚期肝病,包括纤维化相关联.
- 牙周治疗显示出改善肝脏指数的潜力,尽管因果关系仍然未被证明.
结论:
- 有一个生物可信的口腔肝轴存在,牙周炎症与肝损伤相关.
- 牙周评估和治疗可能是牙周炎相关的NAFLD/MASLD的低风险干预措施.
- 需要进一步进行高质量的前性研究和随机试验,以确定因果关系.
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