自然化合物在口腔微生物群调节和空预防:一个系统性审查
María Del Pilar Angarita-Díaz1, Lilia J Bernal-Cepeda2, Jéssica María Sarmiento-Ordoñez3
1GIOMET Group, Faculty of Dentistry, Universidad Cooperativa de Colombia-Campus of Villavicencio, Villavicencio 500001, Colombia.
Dentistry journal
|November 26, 2025
概括
某些天然化合物在平衡口腔微生物群和对抗腔方面表现有前途. 需要进一步的研究来证实这些天然产品的抗癌效应.
科学领域:
- 口腔健康研究 口腔健康研究
- 微生物学 微生物学
- 自然产品化学 自然产品化学
背景情况:
- 天然产品的成分可以帮助保持口腔微生物群平衡,促进口腔健康.
- 识别具有抗 cariogenic 特性的天然成分对于开发预防牙损伤的预防策略至关重要.
- 来自体内研究的现有证据需要进行系统的评估.
研究的目的:
- 系统地审查体内研究,确定具有抗原性质的天然成分.
- 分析这些天然成分对口腔微生物群和牙损的影响.
- 评估天然产品在预防牙损伤方面的疗效的总体证据.
主要方法:
- 按照PRISMA指南进行的系统审查.
- 在英语语言研究 (2013-2025) 的多个数据库中进行文献搜索.
- 包括对所有年龄段的参与者影响口腔健康的自然成分的干预和比较研究.
主要成果:
- 包括77项研究,主要是儿科患者的临床试验.
- 通常研究的成分:益生菌,植物提取物,糖替代品,,氨酸,乳制品.
- 报告了对生物危险因素 (72.8%) 的显著影响;16.9%的研究显示牙损伤的统计显著减少.
结论:
- 初步证据表明,天然化合物可以调节化因子.
- 需要进一步进行高质量的研究来加强证据基础.
- 审查协议在开放科学框架上注册.
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