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在外围神经管中再生微环境重建的生物材料和水凝策略

Wenjing Zhang^1,2,3, Yang Zhang¹, Hailin Ma¹

¹Shenzhen Clinical Research Center for Trauma Treatment, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China.

Gels (Basel, Switzerland)

|November 26, 2025

概括

外周神经损伤 (PNI) 修复面临着当前神经移植的挑战. 先进的神经引导管道 (NGCs) 通过优化神经再生的微环境,改善结果,显示出有希望.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
神经科学是一个神经科学.

背景情况:

周围神经损伤 (PNI) 会导致显著的功能损失和慢性疼痛.
自主神经移植受到供体部位问题和组织可用性的限制.
目前的神经引导管道 (NGCs) 由于不理想的微环境,无法完全支持神经再生.

研究的目的:

审查最近在重建NGC微环境中取得的进展,以加强外围神经修复.
突出生物材料策略,特别是水凝,用于空间时间控制的再生.
概述下一代NGC的设计原则,以弥合有效性差距.

主要方法:

对NGC微环境工程的最新研究进行综合.
专注于NGC中的施万细胞激活,免疫调节和血管生成.
强调先进的水凝生物材料,整合物理,生化和动态线索.

主要成果:

重建NGC微环境是有效的外围神经再生的关键.
策略包括调节施万细胞,调节免疫反应,促进血管生成.
先进的水凝为时空编程的再生提供了可调节的平台.

结论:

优化NGC微环境对于克服外围神经修复的局限性至关重要.
下一代NGC需要动态,特定阶段的生物信号调节.
生物材料创新,特别是水凝,对于推进NGC技术和临床转化至关重要.

关键词:

生物材料是一种生物材料.这种水凝是水凝.神经引导管道的神经引导管道周围神经受伤的情况一个再生的微环境.

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