牙科医学中的凝输送系统:从受控释放到再生应用
Dragos Ioan Virvescu1, Ionut Luchian1, Oana Cioanca2
1Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gels (Basel, Switzerland)
|November 26, 2025
概括
牙凝输送系统提供局部治疗效益. 本次审查强调了它们在改善口腔健康结果方面的潜力,尽管在广泛的临床采用方面存在挑战.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 牙科治疗学 牙科治疗学
背景情况:
- 基于凝的输送系统在牙科中越来越多地被使用.
- 它们的特性包括生物相容性,可注射性和局部治疗剂的输送.
- 存在各种类型,包括水凝,热敏,粘膜,纳米粒子载荷和刺激响应凝.
研究的目的:
- 审查目前关于牙科中的基于凝的输送系统的证据.
- 突出其结构特征,药物释放机制和临床相关性.
- 识别挑战和机会,以采用它们.
主要方法:
- 对有关牙凝输送系统的现有文献进行系统审查.
- 分析结构性质,释放机制和临床应用.
- 评估临床发现和发现的局限性.
主要成果:
- 粘膜凝增强了牙周口袋中的抗微生物和抗炎药物的有效性.
- 热敏凝允许最小入侵的管理和控制释放.
- 装有纳米粒子的凝提高了药物的稳定性和组织透.
- 刺激响应凝根据环境线索调节药物释放.
- 临床使用表明探测深度降低,伤口愈合改善,细菌负载降低.
结论:
- 凝系统显示出作为牙科疗法的附加剂的显著前景.
- 它们提供了诸如改善患者舒适性和疗效等好处.
- 在凝稳定性,制造,监管和长期证据方面仍然存在挑战.
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