氧化和Nrf2在使用HUVEC对抗由牙周病原体引起的血管内皮功能障碍方面的作用
Gunaraj Dhungana1, Chethan Sampath1, Vineeta Sharma2
1Department of Oral Diagnostic Sciences & Research, School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA.
Cells
|November 26, 2025
概括
牙周多种细菌感染会导致内皮功能障碍. L-Sepiapterin和bardoxolone甲基 (CDDO-Me) 治疗可以防止氧化应激,炎症和亡,这表明血管并发症的治疗潜力.
科学领域:
- 内皮细胞生物学 内皮细胞生物学
- 牙周病药物 牙周病药物
- 血管并发症 血管并发症
背景情况:
- 与牙周炎相关的多菌性感染与血管问题有关.
- 这种联系背后的内皮细胞机制尚未完全理解.
- 红色和色复合体细菌对内皮细胞的研究影响.
研究的目的:
- 研究牙周病原体对内皮质氧化应激,炎症,新陈代谢和亡的影响.
- 评估L-Sepiapterin和bardoxolone甲基 (CDDO-Me) 对感染诱导的内皮功能障碍的保护作用.
主要方法:
- 人类静脉内皮细胞 (HUVEC) 被感染并用L-Sepiapterin或CDDO-Me治疗.
- 评估了氧化 (NO),BH4和活性氧物种 (ROS) 的水平.
- 分析了与炎症,新陈代谢和亡途径相关的基因表达.
主要成果:
- 感染减少了NO和BH4,增加了ROS,激活了炎症途径,并诱导了亡.
- L-Sepiapterin和CDDO-Me治疗恢复了NO,减少了氧化应激和炎症,使新陈代谢正常化,并减轻了亡.
- 而CDDO-Me则表现出更显著的保护作用.
结论:
- 牙周多种细菌感染会导致内皮功能障碍和代谢障碍.
- 在预防与牙周病相关的血管损伤方面,L-Sepiapterin和CDDO-Me显示出有前途.
- 反氧化调节策略可能会带来治疗效益.
关键词:
这是CDDO-MeMe.这是一种L-Sepiapterin.灭症 (apoptosis) 是一种死亡的过程.内皮质功能障碍 在内皮质功能障碍氧化应激是一种氧化应激.牙周病是一种牙周病.这是一种多细菌性感染.更多相关视频
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