口腔健康与心血管疾病之间的系统性联系:当代证据,机制和风险因素影响
Florinel Cosmin Bida1, Florin Razvan Curca1, Raoul-Vasile Lupusoru1
1Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diseases (Basel, Switzerland)
|November 26, 2025
概括
口腔健康和心血管疾病之间存在很强的联系,由炎症和微生物因素驱动. 牙周治疗可能会改善血管健康,但需要更多的研究来确认因果关系.
科学领域:
- 口腔健康 口腔健康
- 心血管疾病 心血管疾病
- 系统性炎症 系统性炎症
背景情况:
- 口腔健康是整体健康不可或缺的一部分.
- 越来越多的证据将口腔疾病,包括牙周病,与心血管疾病 (CVD) 联系起来.
- 机制包括口腔微生物群失衡,全身炎症和药物副作用.
研究的目的:
- 审查有关口腔健康和心血管疾病之间关联的文献.
- 探索潜在的炎症和内皮细胞机制.
- 评估牙周治疗对心血管健康的潜在影响.
主要方法:
- 关于2000-2025年研究的叙事文献综述.
- 在PubMed,Scopus和ScienceDirect进行的搜索.
- 包括观察性,干预性,系统性审查和使用相关关键字的元分析.
主要成果:
- 一致的证据支持慢性牙周炎症与心血管风险之间的关联.
- 促炎性细胞因子和微生物产物的系统传播驱动内皮细胞激活和动脉动脉生成.
- 牙周治疗可以减少全身炎症和改善血管参数,但由于研究异质性,因果关系尚未确定.
结论:
- 通过炎症和内皮途径存在显著的口腔系统连接.
- 牙科和心血管专业人员之间的跨学科合作至关重要.
- 需要进一步的纵向和机制研究来确认因果关系并指导临床实践.
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