在意大利患有多动症儿童中探索线粒体DNA复制数:对神经生物学机制的影响
Luigi Citrigno1, Annamaria Cerantonio1, Ludovico Neri2
1CNR Institute for Biomedical Research and Innovation (IRIB), Loc. Burga, 87050 Cosenza, Italy.
Diseases (Basel, Switzerland)
|November 26, 2025
概括
线粒体DNA复制数 (mtDNA-cn) 在患有注意力缺陷/多动障碍 (ADHD) 的儿童中升高,这表明线粒体功能障碍. 这一发现将神经递质系统,氧化应激和ADHD中的线粒体健康联系在一起.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种神经发育障碍,与行为失调有关.
- 遗传因素和单氨基系统都与此有关,新出现的证据表明在ADHD病理生理学中存在线粒体功能障碍.
- 线粒体DNA复制号 (mtDNA-cn) 可能表明与ADHD相关的神经生物学变化和氧化应激.
研究的目的:
- 在患有ADHD的儿童和青少年中调查线粒体DNA拷贝数 (mtDNA-cn).
- 探索mtDNA-cn,ADHD症状,攻击性行为和特定基因多态 (MAOA,5-HTT) 之间的关系.
主要方法:
- 在56名患有多动症的意大利儿童/青少年和27名健康对照的外周血液中评估mtDNA-cn.
- 通过使用DSM-5标准和康纳斯3评分表来评估ADHD症状和攻击性.
- 进行了MAOA (rs6323,rs1137070) 和5-HTT (rs4795541) 多态的基因型鉴定.
主要成果:
- 与对照组相比,ADHD患者的mtDNA-cn显著增加 (p = 0.002).
- 在具有侵略性行为的ADHD患者中观察到mtDNA-cn的非显著减少.
- 特定的MAOA基因型 (rs6323 TT,rs1137070 CC) 和所有5-HTT rs4795541基因型与ADHD患者的mtDNA-cn与对照组相比较高.
结论:
- 线粒体变化似乎有助于ADHD的病理生理学.
- mtDNA-cn和单氨基基因变体之间的关联表明神经递质代谢,氧化应激和线粒体功能之间存在联系.
- mtDNA-cn可以作为一个外围生物标志物和ADHD的潜在治疗点.
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