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制药剂在混合涂层系统中对纯的腐蚀调节效应

Lara Moreno^1,2, Adrián Belarra-Rodriguez³, Marta Mohedano¹

¹Departamento de Ingeniería Química y de Materiales, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Journal of functional biomaterials

|November 26, 2025

概括

制药产品显著影响质植入物腐蚀. 一些抗生素和抗炎药物加速Mg腐蚀,而阿司匹林抑制它,为可吸收植入物开发提供了洞察力.

科学领域:

生物材料科学生物材料科学
腐蚀工程腐蚀工程
制药化学制药化学制药化学

背景情况:

基于 (Mg) 的植入物由于其生物降解性,对骨再生充满希望.
了解同时使用的药物对Mg植入物腐蚀的影响对于临床成功至关重要.
现有的知识差距阻碍了在药物影响下预测Mg植入体体内Mg植入体的行为.

研究的目的:

研究常见抗生素和抗炎药物对高纯度的腐蚀行为的影响.
评估陶和混合陶/聚合物涂层对药物诱导腐蚀的保护性能.
探索药物功能化涂层所提供的潜在的活性保护机制.

主要方法:

电化学阻抗光谱 (EIS) 和演变试验被用于评估腐蚀率.
一种-- (Ca-P-Si) 陶涂层是通过优化的血电解氧化 (PEO) 开发的.
一种混合涂层是通过通过浸泡涂层将PEO与聚乙烯-烯酸乙烯 (PCL) 顶层结合而制造的.

主要成果:

裸体高纯度Mg在经过修改的细胞培养基中显示出快速腐蚀 (90μm/年).
混合PEO/PCL涂层延迟了5个多小时的腐蚀开始,并将的演变减半.
在6种测试药物中,有5种 (gentamicin,naproxen,streptomycin,ciprofloxacin,paracetamol) 加快了Mg腐蚀;阿司匹林起到了抑制作用.
一种杆菌素功能化的涂层通过不溶性酸盐的形成证明了活性保护.

结论:

药物剂的选择可以显著改变基于Mg的植入物的生物降解率.
混合PEO/PCL涂层为Mg植入物提供了相当大的防腐蚀保护.
药物功能化的涂层,如链杆菌素修饰系统,可以提供增强的,活跃的耐腐蚀性.

关键词:

可生物降解的聚合物聚合物腐蚀抑制剂腐蚀抑制剂混合涂层是一种混合涂层.植入物植入物植入物植入物的含量是多少? 的含量是多少?药物制剂药物制剂的制剂.血电解氧化的氧化过程链杆菌素是一种链杆菌素.

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