微针贴片的体外分析用于通过皮肤递送药物:一种最小侵入性通道到全身循环
Haylee L Wagner1, Tailynn Y McCarty1, Theeraphop Prachyathipsakul2
1Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
ACS biomaterials science & engineering
|November 26, 2025
概括
酸微针贴片为全身药物输送提供了一种最少的侵入性方法. 这些贴片有效释放功能性纳米颗粒,增强治疗生物可用性并使自我管理成为可能.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 纳米颗粒的系统性输送面临着挑战,当前的方法如静脉注射或口服,这些方法存在诸如疼痛和低生物可用性等局限性.
- 开发新的,最少的侵入性输送系统对于提高治疗疗效和患者的服药性至关重要.
研究的目的:
- 开发和评估基于酸盐的微针贴片,用于体外输送各种纳米粒子.
- 评估通过微针贴片传递的纳米颗粒的释放动力学,生物活性,细胞吸收和准能力.
主要方法:
- 制造基于酸盐的微针贴片,装有不同纳米粒子配方.
- 在体外释放研究评估从微针释放的治疗有效载荷.
- 释放的治疗药物的生物活性评估 (例如黄素的抗菌活性).
- 使用纳米粒子 (纳米凝,抗体结合的纳米凝,细胞外囊泡) 在相关细胞系 (癌症和正常乳腺上皮细胞,纤维细胞) 中进行细胞吸收研究.
- 在皮肤样本上使用微针贴片进行ex vivo皮肤透研究.
主要成果:
- 酸微针贴片成功释放了封装的治疗药物,这些药物保持了其生物活性.
- 从微针中释放的黄素显示保留了抗菌活性.
- 纳米凝被癌症和正常乳腺上皮细胞有效地吸收.
- 抗体结合的纳米凝保持了功能准能力.
- 从微针中释放的细胞外囊泡被纤维细胞所吸收.
- 微针贴片证明了ex vivo皮肤表皮的成功透,允许纳米颗粒透到更深层组织中.
结论:
- 酸微针贴片是提供一系列功能纳米颗粒的多功能平台.
- 这种微针系统显示了通过最少的侵入性,自我管理的输送来增强治疗生物可用性的潜力.
- 证明的有效载荷多功能性和皮肤透能力凸显了微针贴片对先进药物输送应用的前景.
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