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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
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在儿科密码球菌脑膜炎后的神经后果

Alison Gifford1, Simran Atulkumar Patel2,3, Masilo Matlakala2,3

  • 1Medical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK.

Journal of fungi (Basel, Switzerland)
|November 26, 2025
PubMed
概括

儿童的密码球菌脑膜炎 (CM) 可以导致长期的神经问题,特别是在那些感染艾滋病毒的人群中. 标准的神经发育评估对于更好的结果和CM后的康复至关重要.

关键词:
克里普托科克斯 (Cryptococcus gattii) 是一个有毒的菌种.这是Cryptococcus neoformans的新型菌.艾滋病病毒 艾滋病病毒 艾滋病病毒这是一种加密球菌脑膜炎.神经发育的神经发育儿科 儿科 儿科视力受损 视力受损 视力受损

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科学领域:

  • 儿科神经学 儿科神经学
  • 传染性疾病 传染性疾病
  • 神经发育障碍 神经发育障碍

背景情况:

  • 对发育中的大脑的传染性侮辱可能会导致终身的神经系统缺陷.
  • 成年加密球菌脑膜炎的幸存者会经历诸如失明和运动软弱之类的后果.
  • 对于幸存于加密球菌脑膜炎的儿童的结果是不太了解的.

研究的目的:

  • 调查儿童中加密球菌脑膜炎的神经和神经发育后果.
  • 为了确定儿童CM幸存者的风险因素和常见的后果.
  • 突出需要标准化神经发育评估的需要.

主要方法:

  • 对PubMed和Ovid全球健康数据库的系统文献综述.
  • 包括已证明患有中枢神经系统密码球菌病的儿童 (<19岁).
  • 分析了来自108个出版物的868名儿童 (截至2024年10月的数据截止).

主要成果:

  • 死亡率为24%.死亡率为24%. 没有记录任何正式的神经发育评估.
  • 20%的幸存者经历了神经系统的后果,高于HIV阳性儿童 (25%).
  • 视力受损 (13%) 是常见的,特别是与*Cryptococcus gattii* (32%). 其他后果包括四肢衰弱,学习困难,听力损失和发作.

结论:

  • 加密球菌脑膜炎对儿童的长期神经系统损伤造成重大风险.
  • 艾滋病毒阳性儿童和患有*C. gattii*脑膜炎的儿童面临更高的风险.
  • 标准化的神经发育评估对于儿童CM幸存者的康复和优化功能结果至关重要.