相关实验视频

Updated: Jan 10, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

多糖体缓解了C57BL/6J小鼠的DSS诱导的慢性结肠炎,并调节了结肠微生物群结构

Yangyu Ma¹, Jingrui Li², Xianling Yuan³

¹National Key Laboratory for Development and Utilization of Forest Food Resources, The College of Food and Health, Zhejiang A&F University, Hangzhou 311300, China.

|November 26, 2025

概括

丹德罗 officinale 多糖 (DOP) 通过改善肠道健康和减少炎症,有效治疗小鼠慢性结肠炎. 这种天然化合物调节肠道微生物群和代谢途径,以获得治疗效益.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

慢性结肠炎是一个日益严重的全球健康问题.
丹德罗 (Dendrobium officinale polysaccharide,DOP) 的治疗潜力正在受到研究.

研究的目的:

研究DOP对小鼠中硫酸 (DSS) 诱导的慢性结肠炎的改善作用.
检查DOP对肠道微生物群和代谢途径的双重调节.

主要方法:

在使用DSS的小鼠中诱导慢性结肠炎.
用不同剂量的叶子或茎DOP或硫素治疗的小鼠.
评估了临床症状,结肠组织学,炎症标志物,紧结蛋白,肠道微生物群组成 (16S rRNA) 和代谢学.

主要成果:

DOP显著降低了结肠炎的严重程度,改善了结肠组织架构,并增加了杯状细胞数量.
DOP上调紧结蛋白 (ZO-1,奥克卢丁) 和抑制的TNF-α.
DOP调节了肠道微生物群,丰富了有益的细菌和减少了病原体,同时调节了纯素和尼古丁酸盐/尼古丁胺胺代谢.

结论:

在小鼠中,DOP有效地减轻DSS诱导的慢性结肠炎.
DOP通过微生物组和代谢组调节来保护肠道屏障的完整性.
DOP证明了慢性结肠炎管理的治疗潜力.

关键词:

丹德罗比亚公办植物 (Dendrobium officinale) 是一种植物.慢性结肠炎是一种慢性结肠炎.我们的肠道微生物群.代谢途径代谢途径聚糖类是一种多糖类.

更多相关视频

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

相关概念视频

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...