肠道微生物群通过Hippuric酸代谢影响小鼠的社会行为
Momona Tsukui1,2, Sosuke Yagishita1, Shinji Tokunaga1
1Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira 187-8502, Tokyo, Japan.
Neurology international
|November 26, 2025
概括
肠道微生物群的代谢物 - - 酸 (HA) 能使小鼠的社会行为正常化. 这表明HA影响调节社会互动的大脑机制,为自闭症谱系障碍提供潜在的治疗见解.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其特征是社会沟通缺陷.
- 肠道微生物群被认为是影响自闭症相关行为的一种非遗传因素,无细菌 (GF) 的小鼠表现出社会沟通障碍.
研究的目的:
- 确定影响小鼠社会行为获取的肠道微生物群依赖因素.
- 研究特定代谢物在调解社会行为和神经化学变化的作用.
主要方法:
- 识别由肠道微生物群产生的代谢物.
- 将已识别的代谢物 (希普酸) 给无菌小鼠.
- 在接受治疗的小鼠中评估社会行为和神经化学标记 (催产素,机密素).
主要成果:
- 希普酸 (HA) 被确定为肠道微生物群依赖的代谢物,对社会行为发展至关重要.
- 口服或腹腔内HA给药使GF小鼠的社会行为正常化.
- HA的使用恢复了催产素和分泌素的表达,这表明激活了分泌素-催产素系统.
结论:
- 酸 (HA) 作为一个关键的媒介,受肠道微生物群的影响.
- HA影响调节社会行为的大脑机制,可能是通过分泌-催产素通路.
- 这些发现强调了肠道微生物组在神经发育和社会行为调节中的作用.
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