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老年人RSV疫苗接种计划:关于RSVpreF疫苗安全性的苏格兰范围研究

Lucy A Cullen¹, Cheryl L Gibbons¹, Ting Shi²

¹Public Health Scotland, Edinburgh EH12 9EB, UK.

|November 26, 2025

概括

双价RSVpreF疫苗在老年人中显示出良好的安全性. 然而,在接种疫苗后,观察到吉兰-巴雷综合征 (GBS) 的风险略微增加.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
流行病学流行病学

背景情况:

呼吸道同胞性病毒 (RSV) 在老年人中引起重大疾病.
在苏格兰,双价RSVpreF疫苗 (Abrysvo®) 已为符合条件的老年人推出.
市场营销后的研究表明,RSV疫苗接种和吉-巴雷综合征 (GBS) 之间存在潜在联系.

研究的目的:

在老年人中评估双价RSVpreF疫苗的安全性.
评估在RSV接种疫苗后发生吉-巴雷综合征 (GBS) 的风险.
监测39种疫苗接种后疾病的住院病例.

主要方法:

进行了回顾性观察与预期 (OE) 和自我控制病例系列 (SCCS) 分析.
数据包括苏格兰74岁至80岁的符合条件的成年人住院的情况.
分析重点集中在8月1日至2024年12月31日的RSV疫苗接种后的时期.

主要成果:

在接种疫苗后的1-28天内,鉴定出患有GBS的住院风险增加.
SCCS分析显示,六种条件的风险增加,在时间调整后,只有GBS仍然显著.
所有10例GBS病例发生在接种疫苗后10-16天,每百万剂量中有46.1例的过度风险.

结论:

针对老年人,RSV疫苗显示出良好的安全性.
在接种疫苗后发现了小,但在统计学上显著的GBS风险增加.
观察到的过度GBS风险与其他研究的发现一致.

关键词:

接种RSV疫苗的方法不良事件不良事件不良事件免疫接种免疫接种免疫接种人们对疫苗的信心.疫苗安全性疫苗安全性

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