COVID-19疫苗接种,住院率和死亡率在被诊断为免疫媒介炎症疾病的人和普通人口之间存在差异:基于人口的研究
Carol A Hitchon1, Carole Taylor2, Charles N Bernstein1
1Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Vaccines
|November 26, 2025
概括
接种COVID-19疫苗减少了免疫媒介炎症疾病 (pIMIDs) 患者和普通人口的住院和死亡. 然而,pIMIDs仍然面临更高的风险,为未来的疫苗接种策略提供了信息.
科学领域:
- 免疫学和传染病的研究
- 公共卫生 公共卫生
- 类风湿病学 类风湿病学
背景情况:
- 接种疫苗对于减轻冠状病毒病-19 (COVID-19) 严重程度至关重要.
- 患有免疫媒介性炎症性疾病 (pIMIDs) 的人可能对疫苗接种有不同的反应.
- 与一般人群相比,评估pIMIDs中的COVID-19疫苗有效性至关重要.
研究的目的:
- 为了评估pIMIDs与普通人群的COVID-19疫苗接种情况.
- 为了比较COVID-19疫苗接种在减少住院和死亡率方面的有效性,在pIMIDs和比较者之间进行比较.
- 为正在进行的pIMIDs疫苗接种建议提供信息.
主要方法:
- 基于人口的行政健康记录被用于识别免疫媒介炎症疾病 (IMIDs) 的队列,并匹配了一般人口的比较器.
- 队列包括患有类风湿性关节炎,全身性自身免疫性类风湿性疾病,炎症性肠病,多发性硬化症和牛皮的患者.
- 在2021年1月至2022年3月期间,评估了COVID-19疫苗接种率,COVID-19 (Hosp-C) 住院率和全因死亡率.
主要成果:
- 与普通人群 (84.7%) 相比,在pIMID中观察到更高的疫苗接种率 (87.3%).
- 与对比者相比,pIMIDs的COVID-19住院率 (79对51每10万人) 和死亡率 (3.61%对2.61%) 较高.
- 在两组中,接种疫苗与住院和死亡的减少有关,而pIMIDs和对比剂之间这种保护作用没有显著差异.
结论:
- 接种COVID-19疫苗显著降低了pIMID和普通人口住院和死亡的风险.
- 尽管接种了疫苗,但pIMIDs仍然存在较高的COVID-19相关住院和死亡风险.
- 这些发现支持正在进行的疫苗接种建议,特别是对于pIMIDs,因为SARS-CoV-2变得流行.
关键词:
在 COVID-19 疫情中,管理卫生数据 管理卫生数据住院治疗 住院治疗免疫媒介性炎症性疾病是一种免疫媒介性炎症性疾病.炎症性肠病是一种炎症性肠病.死亡率 死亡率多发性硬化症多发性硬化症牛皮是一种牛皮.类风湿性关节炎 类风湿性关节炎系统性自身免疫性类风湿性疾病疫苗 疫苗 疫苗 疫苗更多相关视频
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