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巴拿马的HPV疫苗摄入量和子宫癌趋势:未来影响研究的参考点

Arlene Calvo¹, Sabrina Hall^1,2, Verónica B Melgar Cossich¹

¹College of Public Health, University of South Florida, Tampa, FL 33612, USA.

|November 26, 2025

概括

巴拿马的HPV疫苗接种率很高,但帕普检测覆盖率很低,导致宫癌死亡率上升,尽管发病率下降. 需要综合战略来改善早期检测和解决预防障碍.

科学领域:

公共卫生公共卫生
在瘤学瘤学.
流行病学流行病学

背景情况:

宫癌 (CC) 仍然是拉丁美洲重要的公共卫生问题.
巴拿马在疫苗接种基本计划 (EPI) 中率先实施了HPV疫苗接种.
该国最近通过了90:70:90的PAHO/WHO战略,以消除CC.

研究的目的:

分析巴拿马关于HPV疫苗接种,查和CC发病率/死亡率的国家数据.
为了确定历史趋势,当前的差距,以及未来的研究方向,以预防CC.
建立一个基准来评估干预措施对消除CC的影响.

主要方法:

一个以人口为基础的,描述性的,观察性的,生态研究.
根据年份,性别和行政划分的四个综合,非识别的国家数据源的匹配合并.
对HPV疫苗覆盖率,CC发病率和死亡率,帕普检测查和诊断时的CC阶段的分析.

主要成果:

较高的HPV疫苗接种率 (大多数年≥85%) 与较低的帕普检测覆盖率 (~10%) 相比.
自20世纪90年代以来,CC发病率的持续下降被观察到.
CC死亡率显著增加,大多数病例是在年轻女性 (30-69岁) 侵袭性阶段被诊断出来的.

结论:

高水平的HPV疫苗接种和发病率下降是积极的指标.
持续的低查率和不断上升的死亡率,特别是年轻女性的侵入性CC,揭示了预防的关键差距.
综合策略对于加强数据系统,增强早期检测,克服结构性/社会文化障碍是必不可少的.

关键词:

这种疫苗是HPV疫苗.巴拿马巴拿马巴拿马巴拿马巴拿马帕普检测是为了测试.宫癌:子宫癌是一种癌症.接种疫苗的情况

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