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Updated: Jan 10, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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发现了VU6052254:一种新的,强大的M1正模拟器

Julie L Engers1,2, Joseph D Bungard1,2, Christopher C Presley1,2

  • 1Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

ACS chemical neuroscience
|November 26, 2025
PubMed
概括

研究人员开发了VU6052254,一种新型的肌酸乙胆受体亚型1 (M1) 阳性全调节器,以克服先前候选者的药理动力学限制. 尽管有前途的属性,但由于潜在的安全问题,开发被停止了.

关键词:
认知 认知 认知代谢过程中的代谢.肌肉酸乙胆受体亚型1 (M1) 的肌肉酸乙胆受体积极的全调节器 (PAM)三级酒精的第三级酒精.

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