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在中国宁省的肉中对感染性贫血病毒的流行病学调查和分子鉴定

Yufu Li^1,2, Zhenyu Chen², Yiyang Huang²

¹College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.

Veterinary sciences

|November 26, 2025

概括

贫血病毒 (CAV) 仍然在中国宁普遍存在,C1亚型占主导地位. 分析揭示了在流通的菌株中潜在的高致病性和传播,影响了家禽养殖.

科学领域:

兽医病毒学兽医病毒学
禽类的健康禽类的健康
分子流行病学分子流行病学

背景情况:

贫血病毒 (CAV) 通过准免疫系统,显著影响家禽养殖,导致贫血和器官缩.
了解CAV的流行率和遗传多样性对于在 brojiler种群中有效管理疾病至关重要.

研究的目的:

调查贫血病毒 (CAV) 在中国宁省肉养殖场的现状和进化趋势.
分析流通的CAV菌株的遗传特征和潜在病原性.

主要方法:

从宁省11个城市的肉养殖场收集和分析了359个肝脏样本 (2024年4月至2025年3月).
使用聚合酶链反应 (PCR) 检测CAV.
对16个完整的CAV基因组序列的遗传学,重组和氨基酸序列分析.

主要成果:

整体CAV阳性率为13.9%,春季是高峰季节.
在分析的16种CAV菌株中,有10种属于C1亚组,其他属于C2,C3和D组.
在VP1蛋白质基因型中发现了与增强的致病性和传播相关的突变,并检测到了一个潜在的重组菌株 (LN2511).

结论:

在宁省,CAV感染很普遍,C1亚型是2024-2025年期间的主导基因型.
特定突变的存在和潜在的重组菌株表明正在进行的病毒进化和潜在的增加病原性.
这些发现为中国的CAV流行病学和遗传多样性提供了关键的见解,为未来的控制策略提供了信息.

关键词:

中国中国中国中国.宁省宁省是一个省.的贫血病毒病毒.流行病学调查调查.基因组基因组是基因组的组成部分.再组合分析的分析.

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