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菌毒素和肠表皮:从屏障损伤到干细胞功能障碍
Wenying Huo1, Yingying Qiao1, Xiangru He2
1College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Toxins
|November 26, 2025
概括
菌毒素通过破坏肠道屏障和损害肠道干细胞 (ISC) 再生来损害肠道健康. 本综述强调了像脱氧尼瓦伦醇这样的毒素如何影响ISC功能和粘膜修复,影响食品安全和人类健康.
科学领域:
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
- 食品安全 食品安全
背景情况:
- 菌毒素污染食品,对人类和动物健康构成风险.
- 胃肠道是主要的暴露部位,肠表皮作为关键的屏障.
- 虽然已知菌毒素对上皮完整性的影响,但它们对肠道干细胞 (ISC) 和再生的影响不太清楚.
研究的目的:
- 审查当前关于真菌毒素如何影响肠道干细胞区和上皮细胞再生的知识.
- 整合各种模型的发现,包括体内细胞培养,细胞培养和先进的有机体/肠上芯片系统.
- 识别知识缺口,并提出未来的研究方向,在真菌毒素毒理学.
主要方法:
- 文献综述整合了体内研究,细胞培养实验和先进的3D肠道有机体和肠上芯片模型的数据.
- 分析菌毒素对ISC增殖,Wnt/Notch信号和粘膜修复机制的影响.
- 讨论影响毒性的因素,包括剂量,物种,微生物群和同时暴露.
主要成果:
- 毒素,如deoxynivalenol和zearalenone,损害ISC的扩散,并改变关键信号通路,如Wnt/Notch.
- 这些毒素会损害肠道粘膜的修复和再生能力.
- 同时暴露可能导致添加剂或协同作用的毒性作用,其中微生物群和SCFA发挥调节作用.
结论:
- 毒素暴露严重损害了肠道干细胞功能和上皮再生,超出了已知的屏障破坏机制.
- 需要综合性模型,将上皮损伤与再生失败联系起来,以充分理解毒素诱导的肠道功能障碍.
- 这些发现为制定保护肠道完整性和促进对菌根毒素污染的修复策略提供了基础.
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