牙周炎和阿尔茨海默病的关系:从表观遗传学的角度来看,相关方面
Tatiana Chacón1, Hernán Hernández-Hincapié2
1Oral Health Department, Universidad Autónoma de Manizales, Manizales, Colombia.
Journal of Alzheimer's disease : JAD
|November 26, 2025
概括
牙周炎症可能通过触发全身炎症和改变大脑表观遗传学,导致阿尔茨海默病 (AD). 基于血液的表观遗传标记显示出早期阿尔茨海默病检测的前景,将口腔健康与神经退行联系起来.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 牙周炎和阿尔茨海默病 (AD) 具有共同的炎症和表观遗传机制.
- DNA甲基化变化影响免疫反应和神经退行.
研究的目的:
- 审查证据,将牙周炎症与阿尔茨海默病发病症联系起来.
- 评估基于血液的表观遗传生物标志物,用于早期阿尔茨海默病诊断和风险分层.
主要方法:
- 临床前和临床研究的叙述性综述.
- 整合了关于DNA甲基化,基因表达和炎症的发现.
- 专注于免疫和补充系统的作用.
主要成果:
- 慢性牙周炎症可能会损害血脑屏障,促进AD病理 (粉样β和).
- 免疫和蛋白质处理基因中的异常DNA甲基化表明共享的途径.
- 血液中的表观遗传变化可能反映大脑变化.
结论:
- 牙周炎症是通过系统性影响和表观遗传修饰对AD病原发生的潜在贡献者.
- 基于血液的表观遗传生物标志物为早期AD检测提供了一个有希望的途径.
- 需要进一步的纵向和干预研究来确认因果关系.
相关概念视频
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Psychoneuroimmunology: Diabetes and Cancer
417
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
417
Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K


