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在人体研究中对电子烟及其对DNA甲基化影响的审查

Naila Francis Paulo de Oliveira¹, Juliana Ramalho Guimarães¹, José Maria Chagas Viana Filho²

¹Department of Molecular Biology, Center for Exact and Natural Sciences, Federal University of Paraíba-UFPB, João Pessoa, Brazil.

|November 26, 2025

概括

电子烟 (e-cig) 使用会改变人类的DNA甲基化概况,其中一些变化与传统香烟 (c-cig) 使用者有所不同. 需要更多的研究来了解这些表观遗传修饰的健康风险.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
毒理学毒理学毒理学
基因组学就是基因组学.

背景情况:

众所周知,使用传统香烟 (c-cig) 导致的DNA甲基化变化.
电子烟 (e-cig) 对DNA甲基化的影响尚不清楚.

研究的目的:

系统地审查和综合关于电子烟使用和DNA甲基化的人类研究.
为了确定与电子烟暴露相关的DNA甲基化概况的变化.

主要方法:

人类研究的范围审查. 人类研究的范围审查.
在2025年4月之前搜索了主要的数据库 (PubMed,Lilacs,Scopus,Web of Science,Cochrane)
包括分析唾液,血液和支气管组织的研究.

主要成果:

七项研究分析了各种人体组织中的DNA甲基化.
与非吸烟者相比,使用电子烟与全球甲基化,特定部位和表观遗传衰老 (GrimAge) 的改变有关.
一些甲基化变化与c-cig用户重叠,而另一些则是电子烟暴露的独特特征.

结论:

电子烟的使用在人体组织中诱导了明显的DNA甲基化变化,有些不同于c-cig效应.
需要进一步研究以确定这些表观遗传变化的长期健康影响.

关键词:

通过DNA甲基化.电子尼古丁输送系统电子尼古丁输送系统电子烟 (e-cig) 是一种电子烟.电子烟是一种电子烟.这是表观遗传学.吸烟是为了吸烟.电子烟 (vaping) 是一种电子烟.

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