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多中心研究:瘤微环境特征与瘤细胞特征相结合,预测早期胃癌的淋巴结转移

Xiaozhuo Gao¹, Xiaoyan Zhao^2,3, Huihui Xu⁴

¹Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), No. 44 of Xiaoheyan Road, Dadong District, Shenyang, 110042, China.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

|November 26, 2025

概括

这项研究开发了一种名图,用于预测早期胃癌中淋巴结转移的情况. 该工具准确地识别瘤微环境中的风险因素,帮助治疗决策.

科学领域:

在瘤学瘤学.
癌症研究癌症研究
医学诊断医学诊断医学诊断

背景情况:

早期胃癌 (EGC) 管理需要准确预测淋巴结转移.
瘤微环境 (TME) 特性越来越被认为对癌症进展至关重要.

研究的目的:

开发和验证 EGC.中淋巴结转移的预测性名谱.
将TME功能纳入EGC治疗优化临床决策工具.

主要方法:

来自三个中心的882名EGC患者的回顾性分析.
量化瘤透淋巴细胞 (TIL),瘤-肌瘤比 (TSR) 和三级淋巴体结构 (TLS).
使用物流回归和验证通过ROC,校准和决策曲线分析进行诺摩图构造.

主要成果:

淋巴结转移率为19.2% (培训) 和23.9% (验证).
确定了独立的风险因素:性别,淋巴血管侵入,TSR和TLS.
诺米图表显示出高的预测准确性 (AUC 0.807培训,0.822验证) 和临床实用性.

结论:

开发的诺米图是准确的,稳定的,并且对EGC临床有用.
该工具可以通过预测淋巴结转移风险,帮助优化EGC患者的治疗策略.

关键词:

早期的胃癌是什么意思淋巴结转移是淋巴结的转移.这个名字叫做Nomogram.预测模型是一个预测模型.瘤微环境是一个微环境.

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