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Updated: Jan 10, 2026

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针对O-GlcNAcylation:神经疾病的新疗法策略

Jingyi Sui1, Lei Zheng2, Baiwen Zhang2

  • 1Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin, China.

Molecular neurobiology
|November 26, 2025
PubMed
概括

与O相关的N-乙糖胺 (O-GlcNAc) 修饰在大脑中至关重要,影响神经功能和疾病. 向O-GlcNAc通过改善认知和减少炎症来治疗大脑疾病有希望.

关键词:
神经退行发生神经退行.神经病变是一种神经病变.这就是O-GLcNAcc.一次性中风,中风.

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Proteoglycans01:05

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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