基于中国市政自发报告系统的离子对比介质不良反应的数据挖掘
Wen-Ting Zhang1, Wei-Jie Li1, Jin-Wen Zhang1
1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Current medical science
|November 26, 2025
概括
类对比介质 (ICM) 的不良药物反应 (ADR) 大多是轻微的,皮疹和是常见的. 像过敏性休克这样的严重反应发生在9.69%的病例中,需要对高危患者进行监测.
科学领域:
- 放射学和成像学 放射学和成像学
- 药物监督 药物监督 药物监督
- 临床毒理学 临床毒理学
背景情况:
- 质对比介质 (ICM) 提高了CT和MRI中的医学成像质量.
- 对ICM的不良药物反应 (ADR) 可以从轻微到严重的全身影响.
- 自发报告系统 (SRS) 对于监测药物安全至关重要.
研究的目的:
- 用中国的SRS数据来评估ICM相关的ADR.
- 识别常见的副作用,其严重程度和患者的特征.
- 为明智的临床实践和患者安全提供数据.
主要方法:
- 分析了来自武汉SRS的4种ICM (约迪克桑醇,iohexol,ioversol,iomeprol) 的2166份ADR报告.
- 从2018年1月1日到2023年12月31日收集的数据.
- 评估ADR的比例,严重程度,症状和患者因素.
主要成果:
- 大多数ICM不良反应是轻微的 (皮疹,最常见).
- 过敏性休克发生在9.69%的严重反应中.
- 夏季ADR发生率较高;受影响患者中流行的循环系统疾病.
结论:
- 监测高风险患者 (老年人,先前存在的疾病) 是至关重要的.
- 及时干预对于严重的ICM反应至关重要.
- 需要进一步的前性研究来进行个性化的ICM选择.
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