对精神病和物质使用障碍的遗传风险采用设计
Kenneth S Kendler1,2, Henrik Ohlsson3, Jan Sundquist3,4
1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
JAMA psychiatry
|November 26, 2025
概括
父亲遗传风险显著影响后代.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 传统的收养研究研究了疾病的亲子传播.
- 父母遗传风险可以通过父母的表型间接影响后代的风险.
- 了解遗传和养育影响对于心理健康研究至关重要.
研究的目的:
- 评估父系家族遗传风险评分 (FGRSs) 的遗传和养殖影响的相对重要性.
- 为了检查这三对疾病的这些影响:内化 (严重抑郁症[MD]和焦虑症[AD]),物质使用 (酒精使用障碍[AUD]和药物使用障碍[DUD]) 和严重 (双极性障碍[BD]和精神分裂症[SZ]).
主要方法:
- 一项瑞典队列研究分析了来自国家登记册的父亲及其生物和收养后代 (1955-1990年出生) 的数据.
- 在完整家庭中检查的父亲,与父亲不住在一起的父亲,继父,收养父亲和被收养的亲生父亲.
- 使用考克斯比例危险比率来评估父亲遗传风险和对后代诊断的影响.
主要成果:
- 从父亲到后代的间接遗传影响在所有类型的疾病中都被观察到.
- 对物质使用障碍 (AUD,DUD) 的养育效应最强,对内化障碍 (MD,AD) 适度较小,对严重障碍 (BD,SZ) 缺席.
- 在单独抚养的关系中,内化和物质使用障碍的父亲遗传风险预测了MD和AUD的后代风险增加.
结论:
- 这种新的收养设计提供了对后代心理病理学的遗传和养育影响的见解.
- 父亲的间接遗传影响在后代疾病风险中起着重要作用.
- 养殖环境和遗传倾向相互作用,影响精神健康障碍的传播.
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