儿童发育模式年龄4年跨子类型的高血压疾病的怀孕
Geng Chen1, Mami Ishikuro1,2, Hisashi Ohseto3
1Graduate School of Medicine, Tohoku University, Sendai, Japan.
JAMA network open
|November 26, 2025
概括
胎儿暴露于早期发作的孕前会增加儿童发育迟缓的风险,特别是在解决问题的技能方面. 过早分娩可以改变这些影响,强调需要监测.
科学领域:
- 发育儿科 发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 流行病学 流行病学
背景情况:
- 妊娠高血压障碍 (HDP) 与儿童发育迟缓有关.
- HDP亚型与儿童纵向发育模式之间的特定关联尚未得到充分理解.
研究的目的:
- 调查妊娠高血压疾病 (HDP) 的亚型与儿童随时间发展的模式之间的关系.
- 为了确定与不同HDP暴露相关的特定发展轨迹.
主要方法:
- 来自东北医疗大银行项目出生和三代队列研究中的母婴对的前性队列研究.
- 通过产前记录确定妊娠高血压障碍 (HDP);在五个领域评估6,12,24,42,48个月的儿童发育.
- 隐性类轨迹建模和多项普森回归用于分析发育模式和相关风险,并对早产子组进行分析.
主要成果:
- 发现了三个发育模式:正常,延迟和赶上.
- 早期发病的孕前显示出在解决问题领域延迟模式的风险明显更高 (RR, 2.90).
- 观察到HDP亚型与发育迟缓之间的关联,但并不总是统计学上显著;早产改变了研究结果.
结论:
- 胎儿暴露于早期发病的孕前与儿童延迟解决问题的能力的风险增加有关.
- 过早出生会影响HDP暴露与发育结果之间的关系.
- 在子宫内暴露于HDP亚型的儿童,特别是早产儿,需要密切监测他们的发育.
相关概念视频
Hypertension III: Clinical Manifestations and Diagnostic Studies
433
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
433
Hypertension I: Introduction
653
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
653
Attention-Deficit/Hyperactivity Disorder
709
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
709
Alterations in Blood Pressure
1.9K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.9K
Hypertension V: Nursing Management
328
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
328
Hypertension II: Pathophysiology
698
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
698


