162毫克和81毫克阿司匹林用于预防产前的比较:随机对照试验
Amrin Khander1, Charlene Thomas, Kathy Matthews
1Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, the Division of Biostatistics and Epidemiology, the Department of Research in Population Health Sciences, the Division of Nephrology, Department of Medicine, and the Department of Obstetrics & Gynecology, Weill Cornell Medicine, New York, and SUNY Downstate Health Sciences University College of Medicine, Brooklyn, New York; New Jersey Perinatal Associates, Cooperman Barnabas Medical Center, Livingston, New Jersey; the University of Miami Miller School of Medicine, Miami, Florida; and the University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
81毫克和162毫克的每日阿司匹林剂量在预防早产前或具有严重特征的早产前方面表现出类似的有效性. 高风险的孕妇经历了相似的结果,无论使用的阿司匹林剂量如何.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 孕前是一种严重的妊娠并发症.
- 阿司匹林通常用于高风险个体的妊娠前预防.
- 预防的最佳阿司匹林剂量仍在调查中.
研究的目的:
- 为了比较每日162毫克阿司匹林与81毫克阿司匹林在预防早产前或具有严重特征的早产前方面的有效性.
- 评估二次结果,包括孕产妇和新生儿并发症.
主要方法:
- 实用,随机,开放标签,盲目的终点临床试验进行.
- 在怀孕16周之前,高危孕妇每天接受162毫克或81毫克阿司匹林.
- 主要组合结果由盲目的研究人员判断;随访延长到分娩后6周.
主要成果:
- 在162毫克 (14.1%) 和81毫克 (17.1%) 的阿司匹林组 (RR 0.83,P=.4) 之间,早产子或具有严重特征的早产子的发生率相似.
- 单子出生体重在162毫克组略低 (2.9公斤对3.2公斤,P=.005).
- 在162毫克组中发生了8例胎盘断裂,而在81毫克组中为零 (P=.013).
结论:
- 在高危人群中,每日81毫克和162毫克的阿司匹林剂量在预防早产前或具有严重特征的早产前方面表现出类似的有效性.
- 这项研究表明,在两个阿司匹林剂量之间,主要结果没有显著差异.
- 需要考虑的是,随着阿司匹林剂量增加,胎盘断裂的潜在风险增加.
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