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相关概念视频

RNA-seq03:21

RNA-seq

11.7K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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相关实验视频

Updated: Jan 10, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

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人类-scATAC-Corpus:一个全面的scATAC-seq数据数据库.

Xiaoyang Chen1, Zijing Gao1, Keyi Li1

  • 1Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division at the Beijing National Research Center for Information Science and Technology, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing  100084, China.

Nucleic acids research
|November 26, 2025
PubMed
概括
此摘要是机器生成的。

我们开发了Human-scATAC-Corpus,这是一个大型数据库,使用测序 (scATAC-seq) 数据对转化酶可访问的染色质进行人类单细胞测试. 这个资源统一了表观遗传学景观,用于各种下游分析和基础模型预培训.

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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

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相关实验视频

Last Updated: Jan 10, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

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科学领域:

  • 基因组学就是基因组学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 计算生物学 计算生物学

背景情况:

  • 使用测序 (scATAC-seq) 检测转化酶可访问性染色质的单细胞检测提供了染色质可访问性的细胞分辨率.
  • 不同质的数据和复杂的管道阻碍了统一的表观基因资源的创建.
  • 现有的资源缺乏全面整合,以满足各种分析需求.

研究的目的:

  • 建立一个全面,统一和可扩展的人类scATAC-seq数据的数据库.
  • 促进各种下游分析,方法开发和基础模型预培训.
  • 为评估单细胞表观遗传学分析提供一个标准化的平台.

主要方法:

  • 来自35个scATAC-seq数据集的5,407,621个细胞在37个人类组织/细胞系中汇编.
  • 数据分布在三个对齐的格式中:细胞对候选 cis-regulatory 元素矩阵,原始片段文件和细胞对峰值矩阵.
  • 集成EpiAgent,一个基础模型预训练在体内进行在线分析.

主要成果:

  • 创建了Human-scATAC-Corpus,这是一个大规模的人类scATAC-seq数据数据库.
  • 提供多种格式的数据,支持跨数据集集成,灵活处理和数据集内部分析.
  • 用于方法基准测试,基础模型预培训和通过EpiAgent.在线分析的资源实用性的演示.

结论:

  • 人类-scATAC-Corpus为人类单细胞表观基因组学提供了一个统一和可扩展的基础.
  • 该数据库加速了单细胞表观基因组研究的发现和标准化评估.
  • 集成的EpiAgent可实现先进的在线分析,提高资源的可访问性和实用性.