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人类-scATAC-Corpus:一个全面的scATAC-seq数据数据库

Xiaoyang Chen¹, Zijing Gao¹, Keyi Li¹

¹Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division at the Beijing National Research Center for Information Science and Technology, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.

Nucleic acids research

|November 26, 2025

概括

我们开发了Human-scATAC-Corpus,这是一个大型数据库,使用测序 (scATAC-seq) 数据对转化酶可访问的染色质进行人类单细胞测试. 这个资源统一了表观遗传学景观,用于各种下游分析和基础模型预培训.

科学领域:

基因组学就是基因组学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
计算生物学计算生物学

背景情况:

使用测序 (scATAC-seq) 检测转化酶可访问性染色质的单细胞检测提供了染色质可访问性的细胞分辨率.
不同质的数据和复杂的管道阻碍了统一的表观基因资源的创建.
现有的资源缺乏全面整合,以满足各种分析需求.

研究的目的:

建立一个全面,统一和可扩展的人类scATAC-seq数据的数据库.
促进各种下游分析,方法开发和基础模型预培训.
为评估单细胞表观遗传学分析提供一个标准化的平台.

主要方法:

来自35个scATAC-seq数据集的5,407,621个细胞在37个人类组织/细胞系中汇编.
数据分布在三个对齐的格式中:细胞对候选 cis-regulatory 元素矩阵,原始片段文件和细胞对峰值矩阵.
集成EpiAgent,一个基础模型预训练在体内进行在线分析.

主要成果:

创建了Human-scATAC-Corpus,这是一个大规模的人类scATAC-seq数据数据库.
提供多种格式的数据,支持跨数据集集成,灵活处理和数据集内部分析.
用于方法基准测试,基础模型预培训和通过EpiAgent.在线分析的资源实用性的演示.

结论:

人类-scATAC-Corpus为人类单细胞表观基因组学提供了一个统一和可扩展的基础.
该数据库加速了单细胞表观基因组研究的发现和标准化评估.
集成的EpiAgent可实现先进的在线分析,提高资源的可访问性和实用性.

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