大规模的血清流行病学揭示了tau自身免疫的人的-泌尿病理病理
Andreia D Magalhães1, Marc Emmenegger1, Elena De Cecco1
1Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
PLoS biology
|November 26, 2025
概括
在一般人群中,高水平的抗tau自身抗体 (ατ) 是常见的,特别是在老年妇女和医院患者中. 这种tau自身免疫与脏和尿路疾病有关,而不是神经疾病.
科学领域:
- 神经免疫学 神经免疫学
- 这是一种自身免疫力.
- 老年学是指老年学的学科.
背景情况:
- 内神经聚合物是阿尔茨海默病和其他神经退行性疾病的核心.
- 反tau抗体在临床前模型中显示出治疗潜力,并正在人类研究中.
研究的目的:
- 为了研究抗tauIgG自身抗体 (ατ) 的患病率和临床关联,在一个大型的人类队列中.
- 探索tau自身免疫和神经与外神经疾病之间的关系.
主要方法:
- 一项大规模的血清流行病学研究分析了40,497个人体血样本,检测出高位抗tau自身抗体 (ατ).
- 统计分析以确定与年龄,性别,医院患者状态和各种疾病类别的关联.
主要成果:
- 高位数的ατ自身抗体普遍存在 (1.6%在健康捐赠者中,4.8%在医院患者中),随着70岁及以上的年龄在女性中增加.
- ατ选择性地结合tau,抑制了其体外聚合,并干扰了血检测.
- 没有发现与神经系统疾病的关联;然而,与脏 (RR 1.27) 和泌尿系统疾病 (RR 1.40) 观察到显著的关联.
结论:
- 反tau自身抗体 (ατ) 是一种常见的自身免疫形式,在医院患者和老年人中患病率明显高.
- 自身免疫意外地与神经外疾病,特别是脏和尿路疾病有关,这表明一种新的疾病关联.
- 这些发现挑战了对神经退行症的专注,并突出了ατ在更广泛的系统健康中的潜在作用.
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