多营养Fortasyn连接影响肠道微生物群和肠道功能在早期阿尔茨海默病的疾病
Natalia Molinero1, Marta Montero-Atalaya1, Lucía Méndez2
1Institute of Food Science Research (CIAL), CSIC-UAM, Madrid, Spain.
Aging and disease
|November 26, 2025
概括
像Fortasyn Connect这样的营养补充剂通过对肠道微生物组产生积极影响并减少炎症,对早期阿尔茨海默病 (AD) 显示出希望. 这在老年人中支持肠-大脑轴健康.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 营养补充剂是早期阿尔茨海默病 (AD) 管理的潜在策略.
- 肠道微生物群通过微生物群-肠道-大脑轴在阿尔茨海默病中发挥作用.
- 福塔辛连接是一种多营养成分配方,研究其效果.
研究的目的:
- 为了研究Fortasyn Connect在AD早期对肠道微生物群的影响.
- 评估微生物组成的变化,短链脂肪酸 (SCFA) 生产和炎症标志物.
- 探索对肠-大脑平衡和全身营养水平的影响.
主要方法:
- 双重方法:体外动态胃肠道模拟器 (simgi®) 和早期阿兹海默症患者的观察性研究.
- 用AD患者便对simgi®进行注射,以进行宿主独立分析.
- 来自补充和非补充AD患者的便样本的分析 (n=22).
主要成果:
- 在体外:增加了Bifidobacterium,Lactobacillus和SCFA的产生.
- 在患者中:比菲多细菌和克里斯氏菌的丰富度更高,炎症标志物 (calprotectin, myeloperoxidase) 减少,酸盐增加.
- 便分析显示,脂质消化改善,分泌IgA增加,宿主蛋白调节;全身铁,叶酸和B12水平增加.
结论:
- 在AD早期,Fortasyn Connect有益地调节了肠道生态系统.
- 补充剂通过肠-大脑轴影响与AD相关的免疫代谢途径.
- 这项研究提供了针对早期阿尔茨海默病老年人的肠-大脑轴机制的证据.
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