每日使用莫斯诺登维尔作为控制人类感染模型中的登革热预防
Anna P Durbin1, Liesbeth Van Wesenbeeck2, Kristen K Pierce3
1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore.
The New England journal of medicine
|November 26, 2025
概括
高剂量的莫斯诺登维尔在人类感染模型中显著降低了登革热病毒3型RNA负载. 这种抗病毒药物显示出作为潜在的登革热治疗的希望,没有观察到严重的不良事件.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 抗病毒研究 抗病毒研究
背景情况:
- 登革热影响全球一半的人口,没有可用的抗病毒治疗方法.
- 目前的登革热预防依赖于载体控制和支持性护理.
研究的目的:
- 在受控的人类感染模型中评估口服莫斯诺登维尔对3型登革热病毒 (DENV-3) 的疗效和安全性.
- 为了确定莫斯诺登维尔对抗病毒活性的最佳剂量.
主要方法:
- 一个2a期,双盲,随机试验,涉及健康的成年人,他们被挑战了低衰减的DENV-3菌株.
- 参与者接受了低,中,或高剂量的口服莫斯诺登维尔,或安慰剂.
- 主要终点:DENV-3 RNA负载 (log10 AUC D1-29);次要终点:安全性,药理动力学,病毒学和血清学特征.
主要成果:
- 高剂量莫斯诺登维尔导致60%的参与者没有感染,而安慰剂为0%.
- 在高剂量莫斯诺登维尔与安慰剂 (P<0.001) 相比,观察到显着较低的DENV-3RNA负载 (log10 AUC D1-29).
- 没有报告严重的不良事件;病毒NS4B变异出现在mosnodenvir接受者中.
结论:
- 高剂量口服莫斯诺登维尔在受控的人类感染模型中显著降低了DENV-3RNA负载.
- 莫斯诺登维尔是安全的,耐受性很好,没有严重的不良事件.
- 进一步调查mosnodenvir作为潜在的登革热治疗药物是有必要的.
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