住院患者的失眠:系统性审查和网络元分析
Dario Bottignole1, Giulia Balella1, Matteo Minetti2
1Neurology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy; Sleep Disorders Center, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy; "Mario Giovanni Terzano" Interdepartmental Center for Sleep Medicine, Department of Medicine and Surgery, University of Parma, Parma, Italy.
住院患者经常经历失眠,影响康复和增加死亡率. 本综述比较了住院患者失眠的药物治疗方法,强调了对标准化研究方案的需要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
- 临床研究 临床研究
背景情况:
- 失眠影响高达50%的住院患者,导致住院时间更长和死亡率更高.
- 在临床实践和研究中,它经常被忽视,特别是在脆弱人群中.
- 需要有效的药理干预措施来管理住院患者的失眠.
研究的目的:
- 系统地审查和比较住院患者失眠的药理干预措施.
- 为在住院患者中治疗失眠障碍的药物治疗提供一个框架.
- 确定研究缺陷,并为未来的研究提出标准化的协议.
主要方法:
- 来自五个主要数据库的随机对照试验 (RCT) 的系统审查 (2024年1月之前).
- 网络对药物对睡眠质量,延迟,持续时间和觉醒的疗效进行元分析.
- 分析调节因素,如性别,年龄和入学环境.
主要成果:
- 二十九个RCT (1913名患者) 评估了各种药物类别:二类药物,Z类药物,黑色素激动剂,抗抑郁药,抗组胺药,α-2激动剂和补充剂.
- 评估了主观睡眠质量,睡眠延迟,总睡眠时间和夜间觉醒的有效性.
- 很少有研究集中在老年或重症患者身上;结果因缓解因素而有所不同.
结论:
- 本综述为住院患者的药理失眠治疗提供了一个框架.
- 方法上的差异限制了概括性,强调了对标准化研究的需要.
- 建议制定一个简短的方案,以指导未来关于住院患者失眠管理的研究.
更多相关视频
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
04:59Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
Published on: May 30, 2025
相关概念视频
Management of Insomnia
Insomnia
Multiple factors contribute...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
CNS Depressants: Barbiturates and Benzodiazepines
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
