在临床前的模型中,催产素治疗减少了癌症缓解症
Alexandra Sviercovich1, Etsuko Watanabe2, Estefania S Fernandez3
1DAHFMO Unit of Histology and Medical Embryology, and Interuniversity Institute of Myology, Sapienza University of Rome, Italy; Sorbonne Université, Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing (Dev2A), Paris, France; Dept. Of Bioengineering, QB3, Stanley Hall, University of California, Berkeley, USA.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|November 26, 2025
概括
催产素 (OT) 水平在癌症患者和肉肌肌肉中较低. 在临床前的模型中,补充OT可以逆转肌肉损失和改善蛋白质合成,这表明它对癌症缓解症的治疗潜力.
科学领域:
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
- 在瘤学瘤学.
背景情况:
- 催产素 (OT) 对于骨肌肉平衡至关重要,并对抗与年龄相关的肌肉损失 (肉症).
- 在癌症缓冲症中,OT在癌症缓冲症中的作用,这是一种以肌肉消耗为特征的衰弱状况,仍然在很大程度上是未知的.
研究的目的:
- 为了研究癌症患者的OT血清水平及其在sarcopenic肌肉中的表达.
- 评估OT在癌症缓解症的临床前模型中的治疗潜力.
主要方法:
- 测量了癌症患者,卡赫西克患者和对照患者的血清OT水平.
- 在sarcopenic肌肉中评估的OT/OT-受体 (OTR) mRNA.
- 在体外 (肌细胞,肌纤维) 和体内 (癌症缓解模型) 调查的OT效应.
- 使用BONCAT分析了蛋白质合成的分子效应.
主要成果:
- 癌症患者的循环OT水平显著降低.
- 萨尔科佩尼克肌肉显示OTR mRNA表达减少.
- 在体外,OT抵消了瘤诱导的肌原抑制.
- 在体内,OT恢复了肌肉质量,纤维大小和体重,同时降低了肌肉降解标志物 (MuRF1,Atrogin1).
- OT正常化了癌症扰乱的蛋白质合成途径.
结论:
- 减少的催产素和OTR表达与癌症缓解症有关.
- 催产素在抵消癌症肌肉消耗方面显示出显著的治疗潜力.
- 由于其现有的临床批准,催产素可能为癌症缓解症提供一种易于翻译的治疗方法.
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