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微生物代谢物伊米达 propionate调节下丘脑活动和压力诱导的行为

Gulistan Agirman¹, Michael N B Quicho¹, Kaden K Connelley¹

¹Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell host & microbe

|November 26, 2025

概括

肠道微生物代谢物伊米达 propionate (ImP) 将肠道不平衡与大脑变化和压力联系起来. 2型糖尿病中ImP升高会加剧代谢功能障碍和应激反应.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍

背景情况:

肠道微生物组不平衡与代谢障碍有关.
微生物代谢物伊米达 propionate (ImP) 在2型糖尿病中升高,并加剧代谢功能障碍.

研究的目的:

研究细菌产生的ImP如何影响大脑活动,行为和应激反应.
探索ImP在2型糖尿病中的作用及其与肠道疾病的联系.

主要方法:

评估血液和大脑中的ImP水平.
在下丘脑中分析神经元基因表达.
在小鼠模型中评估行为和分子压力特征.
与人类应对压力和饮食行为相关联的ImP水平.

主要成果:

升高的循环ImP到达大脑,改变下丘脑基因表达和破坏神经递质信号传递.
产生ImP的细菌,如Eggerthella lenta诱导与压力相关的行为.
患有2型糖尿病的小鼠表现出增加的ImP产量和增加的应激反应.
在人类中,较高的ImP水平与下丘脑反应性降低,应对压力受损和情绪性饮食相关.

结论:

伊米达 propionate (ImP) 是一种微生物代谢物,它将肠道失调与改变的下丘脑功能和压力联系在一起.
ImP在2型糖尿病等代谢疾病的病理生理学中发挥着重要作用.
向IMP产生或其影响可能为代谢和与压力相关的疾病提供治疗策略.

关键词:

焦虑是一种焦虑.在下丘脑中,下丘脑伊米达醇 propionate 的使用方法代谢性疾病是代谢性疾病.微生物组是一个微生物组.压力就是压力,压力就是压力.

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