智能生物结合MOF用于向药物输送:白蛋白和环球蛋白对美贝林释放动态的影响
Esra Maltas Cagil1, Lola Yakhshilikova2, Mustafa Ersoz2
1Selcuk University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Biochemistry Division, Konya, Turkey.
Nanomedicine : nanotechnology, biology, and medicine
|November 26, 2025
概括
酸-铁(III) 金属-有机框架 (TF-MOFs) 已被评估为mebeverine (MBV) 在刺激性肠综合征 (IBS) 的交付. TF-GLB显示出向上肠的潜力,尽管两种配方都没有在生理pH下实现最佳释放.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 梅贝维林 (MBV) 是刺激性肠综合征 (IBS) 的抗药,需要通过口服提供保护,防止胃酸和向性肠道释放.
- 最佳的药物输送需要控制释放配置文件,与胃肠道pH值变化相匹配.
研究的目的:
- 为了比较评估梅贝维林 (MBV) 从葡萄酸-铁(III) 金属-有机框架 (TF-MOFs) 释放的释放,与全球蛋白 (TF-GLB) 或人血清白蛋白 (TF-HSA) 功能化.
- 评估这些配方是否适合在胃肠道中向口服药物输送.
主要方法:
- 用MBV装载的TF-GLB和TF-HSA的准备和描述.
- 在体外释放药物的研究涉及多种pH值 (酸性,中性,性).
- 动力建模 (希古奇扩散,Case II传输) 以阐明释放机制.
主要成果:
- 在pH值7.4和9.0下,TF-GLB-MBV的MBV释放量较高,这表明它适合在II种运输的轻度酸性环境中使用.
- TF-HSA-MBV在酸性和性条件下通过希古奇扩散显示出最佳的释放.
- 两种配方都无法在生理pH值7.4.4时实现理想的释放.
结论:
- 作为IBS的口服输送系统,TF-GLB显得有前途,特别是针对上肠向.
- 需要进一步优化配方,以在生理pH值下实现最佳的mebeverine释放.
- 该研究强调了依赖pH值的释放机制在口服药物输送设计中的重要性.
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