慢性压力调节了与急性压力相关的皮质 - 边缘电路功能连接和抑郁症状之间的关系
Menglu Chen1, Mengxia Gao1, Robin Shao1
1State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology & Human Neuroscience, The University of Hong Kong, Hong Kong.
Journal of affective disorders
|November 26, 2025
概括
慢性压力会改变急性压力后的大脑回路的恢复,特别是在高压力的人中. 麻木的神经动态与抑郁症状的增加有关,澄清了压力-大脑-抑郁关系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 慢性压力通过影响大脑功能和情绪调节来提高抑郁风险.
- 在慢性压力条件下的急性压力反应中神经动态的变化尚未得到充分理解.
- 这项研究研究了慢性压力如何影响后急性压力的神经连接 (vmPFC-杏仁体,vmPFC-海马体).
研究的目的:
- 研究慢性压力在急性压力期间和之后对神经反应的影响.
- 为了分析心中前额叶皮层 (vmPFC) - 杏仁体和vmPFC - 海马体电路中的功能连接 (FC) 变化.
- 确定这些FC变化与抑郁症症状之间的关系.
主要方法:
- 87名成年人在基线,急性压力和恢复期间接受了休息状态fMRI.
- 参与者被分为高和低慢性压力组.
- 线性混合效应模型和ANOVA分析了神经动态和FC恢复,与抑郁症得分相关.
主要成果:
- 低慢性压力组显示了从压力到恢复的vmPFC-杏仁体和vmPFC-海马体连接性下降.
- 高慢性压力组在这些连接中没有显著变化.
- 在康复期间vmPFC-杏仁体连接的较大下降与高压力组中较高的抑郁症状有关.
结论:
- 慢性压力在急性应激反应和恢复期间显著改变神经动态.
- 患有高慢性压力的个体表现出皮层-边缘电路动态的化,可能增加抑郁症的脆弱性.
- 这些发现突出了不适应的压力恢复机制,并澄清了压力-大脑-抑郁症的联系.
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