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循环代谢物签名将身体活动与炎症性肠病风险联系起来,以及与遗传易感性相互作用

Zixuan He¹, Yuhao Sun², Hanyi Huang³

¹Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, China; National Key laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

|November 26, 2025

概括

定期体力活动可以通过改变新陈代谢来帮助预防炎症性肠病 (IBD). 这种保护作用在具有更高IBD遗传风险的个体中特别强烈.

科学领域:

代谢学代谢学代谢学
流行病学流行病学
遗传学遗传学是一个

背景情况:

身体活动显示出对炎症性肠道疾病 (IBD) 的保护作用.
这种效应背后的机制及其与遗传敏感性的相互作用尚未得到充分理解.

研究的目的:

研究中度至强度体力活动 (MVPA) 与IBD发病率之间的关系.
确定与MVPA相关的代谢特征及其在IBD预防中的作用.
探索MVPA,代谢特征和IBD的遗传易感性之间的相互作用.

主要方法:

利用来自两个潜在队列 (英国生物银行和惠特霍尔II) 的大规模代谢学数据.
通过调查问卷评估MVPA,并使用NMR对循环代谢组进行了分析.
通过与国家健康记录的联系,确定了IBD事件病例.

主要成果:

确定了与MVPA相关的25种代谢物的代谢特征,表明改善了脂蛋白特征,改变了脂肪酸成分,增强了能量代谢,并减少了炎症.
MVPA及其代谢特征都与IBD (克罗恩病和性结肠炎) 的风险显著降低有关.
代谢特征部分介导了MVPA对IBD的保护作用,并且观察到MVPA,代谢特征和遗传易感性之间的相互作用.

结论:

适度至强烈的体力活动可能在预防IBD方面发挥作用.
受到体力活动影响的代谢途径可能是IBD预防的关键媒介.
在具有更高遗传倾向的个体中,MVPA对IBD的保护作用可能更为明显.

关键词:

遗传风险得分遗传风险得分炎症性肠疾病炎症性肠病代谢学代谢学代谢学适度至强烈的体力活动

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